Welcome to HEDD, an integrated human enhancer disease database  

Overview  

Enhancers are specialized genomic cis-regulatory elements that play a central role in regulating a wide range of important biological functions and processes, whose impairment could result in disease. HEDD, as a central repository of human enhancers and their disease association, can facilitate genomic research of enhancers and their roles in the human diseases. In the current release, HEDD provides the following:
  • 2,793,316 enhancers
  • Comprehensive genomic information on every enhancer, including
    • Conservation score
    • Regulatory target genes
    • Active cell/tissue types
    • Co-regulatory enhancers
    • Local gene regulatory network
    • Functionally significant genetic variants
    • Overlapping genomic elements (DHS, TFBS, histone marks, and repeats)
  • Enhancer-disease association scores
  • Web-based analytical tools for enhancer visualization and scoring
Citation 

If you use HEDD in your work, please cite our publication: Wang Z, Zhang Q, Zhang W, Lin JR, Cai Y, Mitra J, Zhang ZD. HEDD: Human Enhancer Disease Database (2018). Nucleic Acids Res, 46, D113-D120.


References  

[1] The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature, 2012, Vol. 489.

[2] Lizio M, et al. Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biol, 2015, vol.16, 22 .

[3] Roadmap Epigenomics Consortium, Kundaje, Anshul, et.al. Integrative analysis of 111 reference human epigenomes. Nature, 2015, Vol. 518, 317–330.

[4] Aziz Khan, Xuegong Zhang. dbSUPER: a database of super-enhancers in mouse and human genome. Nucleic Acids Research, 2016, Vol. 44, Database issue.

[5] Christophe Lemetre, Quanwei Zhang, Zhengdong D. Zhang. SubNet: a Java application for subnetwork extraction. Bioinformatics, 2013, Vol. 29 no. 19.